In 2013, after helping build one of Las Cruces' most successful startup companies, Congressman Vasquez joined Senator Heinrich's staff and worked across southern New Mexico to solve problems for New Mexico businesses, communities, and families. Vasquez was also instrumental in the designation of the Organ Mountains Desert Peaks National Monument, protecting it from harmful development and safeguarding it for future generations. In 2017, Congressman Vasquez was elected to the Las Cruces City Council with over 70 percent of the vote. In this role, he delivered millions of dollars in investment to create and improve parks, updated the district's infrastructure, promoted policy that created thousands of jobs, and helped craft a comprehensive development plan that focused on lifting families out of poverty. In prior years, Congressman Vasquez has served as the executive director of the Las Cruces Hispano Chamber of Commerce, worked in public lands conservation, and as a policy advocate promoting child welfare and family wellbeing at the federal level.

Vasquez was elected to represent New Mexico's 2nd district in November 2022.